Yes.
For example, Ashwini–Kettai and Kettai–Ashwini are both treated as the same Vedha combination.
About the Author: Rukesh Ganesan
Rukesh G has a strong interest in Tamil astrology, nakshatra analysis, and marriage compatibility. He studied astrology at Sri Sivasakthi Jothishta Vidiyala Academy and has analyzed over 3000+ Thirumana Porutham matches with practical experience in horoscope study.